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1

Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr–Abl positive cells

Tamura, Shu, Buchdunger, Elisabeth, Ohno, Sayuri, Segal, Gerald M., Fanning, Shane, Zimmermann, Jürg, Lydon, Nicholas B., Druker, Brian J.

Journal:

Nature Medicine

Year:

1996

File:

PDF, 617 KB

1996

2

Requirement of Src kinases Lyn, Hck and Fgr for BCR-ABL1-induced B-lymphoblastic leukemia but not chronic myeloid leukemia

Hu, Yiguo, Liu, Yuhua, Pelletier, Shawn, Buchdunger, Elisabeth, Warmuth, Markus, Fabbro, Doriano, Hallek, Michael, Van Etten, Richard A, Li, Shaoguang

Journal:

Nature Genetics

Year:

2004

Language:

english

File:

PDF, 1.24 MB

english, 2004

3

Glivec (STI571, imatinib), a rationally developed, targeted anticancer drug

Capdeville, Renaud, Buchdunger, Elisabeth, Zimmermann, Juerg, Matter, Alex

Journal:

Nature Reviews Drug Discovery

Year:

2002

Language:

english

File:

PDF, 1.04 MB

english, 2002

4

Protein kinases as targets for anticancer agents: from inhibitors to useful drugs

Doriano Fabbro, Stephan Ruetz, Elisabeth Buchdunger, Sandra W Cowan-Jacob, Gabriele Fendrich, Janis Liebetanz, Jürgen Mestan, Terence O'Reilly, Peter Traxler, Bhabatosh Chaudhuri, Heinz Fretz, Jürg Zi

Journal:

Pharmacology & Therapeutics

Year:

2002

Language:

english

File:

PDF, 1.22 MB

english, 2002

5

New Anilinophthalazines as Potent and Orally Well Absorbed Inhibitors of the VEGF Receptor Tyrosine Kinases Useful as Antagonists of Tumor-Driven Angiogenesis

Bold, Guido, Altmann, Karl-Heinz, Frei, Jörg, Lang, Marc, Manley, Paul W., Traxler, Peter, Wietfeld, Bernhard, Brüggen, Josef, Buchdunger, Elisabeth, Cozens, Robert

Journal:

Journal of Medicinal Chemistry

Year:

2000

Language:

english

File:

PDF, 388 KB

english, 2000

6

Use of a Pharmacophore Model for the Design of EGF-R Tyrosine Kinase Inhibitors: 4-(Phenylamino)pyrazolo[3,4- d ]pyrimidines

Traxler, Peter, Bold, Guido, Frei, Joerg, Lang, Marc, Lydon, Nicholas, Mett, Helmut, Buchdunger, Elisabeth, Meyer, Thomas, Mueller, Marcel, Furet, Pascal

Journal:

Journal of Medicinal Chemistry

Year:

1997

Language:

english

File:

PDF, 387 KB

english, 1997

7

A potent protein-tyrosine kinase inhibitor which selectively blocks proliferation of epidermal growth factor receptor-expressing tumor cells in vitro and in vivo

Nicholas B. Lydon, Helmut Mett, Marcel Mueller, Michael Becker, Robert M. Cozens, David Stover, Daren Daniels, Peter Traxler, Elisabeth Buchdunger

Journal:

International Journal of Cancer

Year:

1998

Language:

english

File:

PDF, 243 KB

english, 1998

8

A potent protein-tyrosine kinase inhibitor which selectively blocks proliferation of epidermal growth factor receptor-expressing tumor cells in vitro and in vivo. Int. J. Cancer,76, 154–163 (1998)

N. Lydon, H. Mett, M. Mueller, M. Becker, R.M. Cozens, D. Daniels, P. Traxler, E. Buchdunger, D. Stover

Journal:

International Journal of Cancer

Year:

1999

Language:

english

File:

PDF, 8 KB

english, 1999

9

ChemInform Abstract: Potent and Selective Inhibitors of the AbL-Kinase: Phenylaminopyrimidine (PAP) Derivatives.

J. ZIMMERMANN, E. BUCHDUNGER, H. METT, T. MEYER, N. B. LYDON

Journal:

Year:

1997

File:

PDF, 30 KB

1997

10

ChemInform Abstract: Substituted 5,7-Diphenyl-pyrrolo[2,3-d]pyrimidines: Potent Inhibitors of the Tyrosine Kinase c-Src.

Martin Missbach, Eva Altmann, Leo Widler, Mira Susa, Elisabeth Buchdunger, Helmut Mett, Thomas Meyer, Jonathan Green

Journal:

Year:

2000

File:

PDF, 30 KB

2000

11

ChemInform Abstract: Tyrosine Kinase Inhibitors: From Rational Design to Clinical Trials.

Peter Traxler, Guido Bold, Elisabeth Buchdunger, Giorgio Caravatti, Pascal Furet, Paul Manley, Terence O'Reilly, Jeanette Wood, Juerg Zimmermann

Journal:

Year:

2002

File:

PDF, 25 KB

2002

12

Tyrosine kinase inhibitors: From rational design to clinical trials

Peter Traxler, Guido Bold, Elisabeth Buchdunger, Giorgio Caravatti, Pascal Furet, Paul Manley, Terence O'Reilly, Jeanette Wood, Juerg Zimmermann

Journal:

Medicinal Research Reviews

Year:

2001

Language:

english

File:

PDF, 315 KB

english, 2001

13

Phenylamino-pyrimidine (PAP) — derivatives: a new class of potent and highly selective PDGF-receptor autophosphorylation inhibitors

Jürg Zimmermann, Elisabeth Buchdunger, Helmut Mett, Thomas Meyer, Nicholas B. Lydon, Peter Traxler

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1996

Language:

english

File:

PDF, 316 KB

english, 1996

14

Substituted 5,7-diphenyl-pyrrolo[2,3d]pyrimidines: potent inhibitors of the tyrosine kinase c-Src

Martin Missbach, Eva Altmann, Leo Widler, Mira Šuša, Elisabeth Buchdunger, Helmut Mett, Thomas Meyer, Jonathan Green

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2000

Language:

english

File:

PDF, 6.06 MB

english, 2000

15

Potent and selective inhibitors of the Abl-kinase: phenylamino-pyrimidine (PAP) derivatives

Jürg Zimmermann, Elisabeth Buchdunger, Helmut Mett, Thomas Meyer, Nicholas B. Lydon

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1997

Language:

english

File:

PDF, 279 KB

english, 1997

16

Bcr-Abl kinase promotes cell cycle entry of primary myeloid CML cells in the absence of growth factors

Tarja Jonuleit, Christian Peschel, Renate Schwab, Heiko van der Kuip, Elisabeth Buchdunger, Thomas Fischer, Christoph Huber, Walter E. Aulitzky

Journal:

British Journal of Haematology

Year:

1998

Language:

english

File:

PDF, 1.33 MB

english, 1998

17

Patupilone (epothilone B, EPO906) and imatinib (STI571, Glivec) in combination display enhanced antitumour activity in vivo against experimental rat C6 glioma

T. O’Reilly, M. Wartmann, S.-M. Maira, M. Hattenberger, J. Vaxelaire, M. Muller, S. Ferretti, E. Buchdunger, K.-H. Altmann, P. M. J. McSheehy

Journal:

Cancer Chemotherapy and Pharmacology

Year:

2005

Language:

english

File:

PDF, 491 KB

english, 2005

18

Favorable therapeutic index of a p210BCR-ABL-specific tyrosine kinase inhibitor; activity on lineage-committed and primitive chronic myelogenous leukemia progenitors

Bernd Kasper, Stefan Fruehauf, Bernd Schiedlmeier, Elisabeth Buchdunger, Anthony D. Ho, W. Jens Zeller

Journal:

Cancer Chemotherapy and Pharmacology

Year:

1999

Language:

english

File:

PDF, 170 KB

english, 1999

19

Selective Tyrosine Kinase Inhibitor for the Platelet-Derived Growth Factor Receptor In Vitro Inhibits Smooth Muscle Cell Proliferation After Reinjury of Arterial Intima In Vivo

Marjukka Myllärniemi, Juhana Frösen, Lázaro G. Calderón Ramirez, Elisabeth Buchdunger, Karl Lemström, Pekka Häyry,

Journal:

Cardiovascular Drugs and Therapy

Year:

1999

Language:

english

File:

PDF, 288 KB

english, 1999

20

ChemInform Abstract: Phenylamino-Pyrimidine (PAP)-Derivatives: A New Class of Potent and Highly Selective PDGF-Receptor Autophosphorylation Inhibitors.

J. ZIMMERMANN, E. BUCHDUNGER, H. METT, T. MEYER, N. B. LYDON, P. TRAXLER

Journal:

Year:

1996

File:

PDF, 30 KB

1996

21

Inhibition of collagen-induced discoidin domain receptor 1 and 2 activation by imatinib, nilotinib and dasatinib

Elizabeth Day, Beatrice Waters, Katrin Spiegel, Tanja Alnadaf, Paul W. Manley, Elisabeth Buchdunger, Christoph Walker, Gabor Jarai

Journal:

European Journal of Pharmacology

Year:

2008

Language:

english

File:

PDF, 1.94 MB

english, 2008

22

Inhibitors of Protein Kinases: CGP 41251, a Protein Kinase Inhibitor with Potential as an Anticancer Agent

Doriano Fabbro, Elisabeth Buchdunger, Jeannette Wood, Jürgen Mestan, Francesco Hofmann, Stefano Ferrari, Helmut Mett, Terence O’Reilly, Thomas Meyer

Journal:

Pharmacology & Therapeutics

Year:

1999

Language:

english

File:

PDF, 239 KB

english, 1999

23

Bcr-abl kinase inhibition as the basis of therapy for cml

Brian J. Druker, Moshe Talpaz, Debra Resta, Bin Peng, Eliasbeth Buchdunger, John Ford, Charles L. Sawyers

Journal:

Experimental Hematology

Year:

2000

Language:

english

File:

PDF, 14 KB

english, 2000

24

Bcr-Abl inhibition as a modality of CML therapeutics

Elisabeth Buchdunger, Alex Matter, Brian J. Druker

Journal:

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer

Year:

2001

Language:

english

File:

PDF, 305 KB

english, 2001

25

PDGF receptor inhibition prevents cardiac allograft arteriosclerosis in cholesterol-fed rabbits

K. Lemström, R. Sihvola, J. Tikkanen, E. Aaltola, E. Buchdunger, O. Laitinen, P. Koskinen

Journal:

Transplantation Proceedings

Year:

2001

Language:

english

File:

PDF, 59 KB

english, 2001

26

Prevention of cardiac allograft arteriosclerosis by protein-tyrosine kinase inhibitor selective for platelet-derived growth factor receptor

P Koskinen, R Sihvola, M Myllärniemi, P Häyry, E Buchdunger, K Lemström

Journal:

Transplantation Proceedings

Year:

1999

Language:

english

File:

PDF, 52 KB

english, 1999

27

Inhibition of obliterative bronchiolitis by platelet-derived growth factor receptor protein-tyrosine kinase inhibitor

E Kallio, P Koskinen, E Buchdunger, K Lemström

Journal:

Transplantation Proceedings

Year:

1999

Language:

english

File:

PDF, 54 KB

english, 1999

28

Imatinib: a selective tyrosine kinase inhibitor

P.W. Manley, S.W. Cowan-Jacob, E. Buchdunger, D. Fabbro, G. Fendrich, P. Furet, T. Meyer, J. Zimmermann

Journal:

European Journal of Cancer

Year:

2002

Language:

english

File:

PDF, 618 KB

english, 2002

29

Pharmacology of imatinib (STI571)

Elisabeth Buchdunger, Terence O'Reilley, Jeanette Wood

Journal:

European Journal of Cancer

Year:

2002

Language:

english

File:

PDF, 867 KB

english, 2002

30

363 Targeting of PDGF receptors; combination effects in various solid tumors and identification of a PDGF dependent brain tumor subset

A. Östman, D. Hägerstrand, K. Pietras, M. Furuhashi, Y. Wu, D.J. Hicklin, E. Buchdunger, M. Abe, M. Nister, J. Baranowska-Kortylewicz, C.-H. Heldin

Journal:

European Journal of Cancer Supplements

Year:

2004

Language:

english

File:

PDF, 145 KB

english, 2004

31

Combination of VEGF-C gene transfer and treatment with the PDGF receptor kinase inhibitor STI571 leads to persistent reduction in neointima formation in balloon-denunded rabbit aorta

Olli P. Leppanen, Mikko O. Hiltunen, Tuomas T. Rissanen, Juha Rutanen, Mikko P. Turunen, Tobias Sjöblom, Josef Brueggen, Marianne Carlsson, Elisabeth Buchdunger, David Bergqvist, Karl Alitalo, Carl-He

Journal:

Journal of the American College of Cardiology

Year:

2002

Language:

english

File:

PDF, 298 KB

english, 2002

32

Efficacy and Safety of a Specific Inhibitor of the BCR-ABL Tyrosine Kinase in Chronic Myeloid Leukemia

Druker, Brian J., Talpaz, Moshe, Resta, Debra J., Peng, Bin, Buchdunger, Elisabeth, Ford, John M., Lydon, Nicholas B., Kantarjian, Hagop, Capdeville, Renaud, Ohno-Jones, Sayuri, Sawyers, Charles L.

Journal:

Boston Medical and Surgical Journal

Year:

2001

Language:

english

File:

PDF, 177 KB

english, 2001

33

4-(Phenylamino)pyrrolopyrimidines: Potent and Selective, ATP Site Directed Inhibitors of the EGF-Receptor Protein Tyrosine Kinase

Traxler, Peter M., Furet, Pascal, Mett, Helmut, Buchdunger, Elisabeth, Meyer, Thomas, Lydon, Nicholas

Journal:

Journal of Medicinal Chemistry

Year:

1996

Language:

english

File:

PDF, 274 KB

english, 1996

34

[(Alkylamino)methyl]acrylophenones: Potent and Selective Inhibitors of the Epidermal Growth Factor Receptor Protein Tyrosine Kinase

Traxler, Peter, Trinks, Uwe, Buchdunger, Elisabeth, Mett, Helmut, Meyer, Thomas, Mueller, Marcel, Regenass, Urs, Roesel, Johannes, Lydon, Nicholas

Journal:

Journal of Medicinal Chemistry

Year:

1995

Language:

english

File:

PDF, 1.05 MB

english, 1995

35

New Anilinophthalazines as Potent and Orally Well Absorbed Inhibitors of the VEGF Receptor Tyrosine Kinases Useful as Antagonists of Tumor-Driven Angiogenesis.

Bold, Guido, Altmann, Karl-Heinz, Frei, Jörg, Lang, Marc, Manley, Paul W., Traxler, Peter, Wietfeld, Bernhard, Brüggen, Josef, Buchdunger, Elisabeth, Cozens, Robert, Ferrari, Stefano, Furet, Pascal, H

Journal:

Journal of Medicinal Chemistry

Year:

2000

Language:

english

File:

PDF, 25 KB

english, 2000

36

Dianilinophthalimides: Potent and Selective, ATP-Competitive Inhibitors of the EGF-Receptor Protein Tyrosine Kinase

Trinks, Uwe, Buchdunger, Elisabeth, Furet, Pascal, Kump, Wilhelm, Mett, Helmut, Meyer, Thomas, Mueller, Marcel, Regenass, Urs, Rihs, Greti

Journal:

Journal of Medicinal Chemistry

Year:

1994

Language:

english

File:

PDF, 2.49 MB

english, 1994

37

Preclinical evaluation of the antiproliferative potential of STI571 in Hodgkin's disease

Re, D, Wickenhauser, C, Ahmadi, T, Buchdunger, E, Kochanek, M, Diehl, V, Wolf, J

Journal:

British Journal of Cancer

Year:

2002

Language:

english

File:

PDF, 72 KB

english, 2002

38

In Vivo Eradication of Human BCR/ABL-Positive Leukemia Cells With an ABL Kinase Inhibitor

le Coutre, P., Mologni, L., Cleris, L., Marchesi, E., Buchdunger, E., Giardini, R., Formelli, F., Gambacorti-Passerini, C.

Journal:

JNCI Journal of the National Cancer Institute

Year:

1999

Language:

english

File:

PDF, 183 KB

english, 1999

39

Selective inhibition of the platelet-derived growth factor signal transduction pathway by a protein-tyrosine kinase inhibitor of the 2-phenylaminopyrimidine class.

Buchdunger, E., Zimmermann, J., Mett, H., Meyer, T., Muller, M., Regenass, U., Lydon, N. B.

Journal:

Proceedings of the National Academy of Sciences

Year:

1995

Language:

english

File:

PDF, 1.34 MB

english, 1995

40

Retraction

Buchdunger, E., Trinks, U., Mett, H., Regenass, U., Meyer, T., McGlynn, E., Pinna, L. A., Traxler, P., Lydon, N. B., Zimmermann, J.

Journal:

Proceedings of the National Academy of Sciences

Year:

1998

Language:

english

File:

PDF, 78 KB

english, 1998

41

Role of Platelet-derived Growth Factor in Obliterative Bronchiolitis (Chronic Rejection) in the Rat

KALLIO, ERKKI A., KOSKINEN, PETRI K., AAVIK, EINARI, BUCHDUNGER, ELISABETH, LEMSTRÖM, KARL B.

Journal:

American Journal of Respiratory and Critical Care Medicine

Year:

1999

Language:

english

File:

PDF, 1.02 MB

english, 1999

42

Prevention of Cardiac Allograft Arteriosclerosis by Protein Tyrosine Kinase Inhibitor Selective for Platelet-Derived Growth Factor Receptor

Sihvola, R., Koskinen, P., Myllarniemi, M., Loubtchenkov, M., Hayry, P., Buchdunger, E., Lemstrom, K.

Journal:

Year:

1999

Language:

english

File:

PDF, 558 KB

english, 1999

43

Imatinib mesylate attenuates fibrosis in coxsackievirus b3-induced chronic myocarditis

Leipner, C., Grun, K., Muller, A., Buchdunger, E., Borsi, L., Kosmehl, H., Berndt, A., Janik, T., Uecker, A., Kiehntopf, M., Bohmer, F.-D.

Journal:

Cardiovascular Research

Year:

2008

Language:

english

File:

PDF, 683 KB

english, 2008

44

Selective Inhibition of the Platelet-Derived Growth Factor Signal Transduction Pathway by a Protein-Tyrosine Kinase Inhibitor of the 2- Phenylaminopyrimidine Class

Elisabeth Buchdunger, Jurg Zimmermann, Helmut Mett, Thomas Meyer, Marcel Muller, Urs Regenass and Nicholas B. Lydon

Journal:

Proceedings of the National Academy of Sciences

Year:

1995

Language:

english

File:

PDF, 1.13 MB

english, 1995

45

4,5-Dianilinophthalimide: A Protein-Tyrosine Kinase Inhibitor with Selectivity for the Epidermal Growth Factor Receptor Signal Transduction Pathway and Potent in vivo Antitumor Activity

Elisabeth Buchdunger, Uwe Trinks, Helmut Mett, Urs Regenass, Marcel Muller, Thomas Meyer, Elaine McGlynn, Lorenzo A. Pinna, Peter Traxler and Nicholas B. Lydon

Journal:

Proceedings of the National Academy of Sciences

Year:

1994

Language:

english

File:

PDF, 1.16 MB

english, 1994

46

4,5-Dianilinophthalimide: a protein-tyrosine kinase inhibitor with selectivity for the epidermal growth factor receptor signal transduction pathway and potent in vivo antitumor activity.

Buchdunger, E., Trinks, U., Mett, H., Regenass, U., Muller, M., Meyer, T., McGlynn, E., Pinna, L. A., Traxler, P., Lydon, N. B.

Journal:

Proceedings of the National Academy of Sciences

Year:

1994

Language:

english

File:

PDF, 1.33 MB

english, 1994

47

Platelet-derived growth factor receptor inhibition reduces allograft arteriosclerosis of heart and aorta in cholesterol-fed rabbits

Sihvola, Roope K., Tikkanen, Jussi M., Krebs, Rainer, Aaltola, Eva M., Buchdunger, Elisabeth, Laitinen, Outi, Koskinen, Petri K., Lemstr??m, Karl B.

Journal:

Transplantation Journal

Year:

2003

Language:

english

File:

PDF, 2.04 MB

english, 2003

48

Protein Tyrosine Kinase and Protein Kinase C Inhibition by Fungal Anthraquinones Related to Emodin.

FREDENHAGEN, ANDREAS, METT, HELMUT, MEYER, THOMAS, BUCHDUNGER, ELISABETH, REGENASS, URS, ROGGO, BARBARA E., PETERSEN, FRANK

Journal:

The Journal of Antibiotics

Year:

1995

Language:

english

File:

PDF, 304 KB

english, 1995

49

The selective tyrosine kinase inhibitor STI571 inhibits small cell lung cancer growth.

Krystal, G W, Honsawek, S, Litz, J, Buchdunger, E

Journal:

Clinical cancer research : an official journal of the American Association for Cancer Research

Year:

2000

Language:

english

File:

PDF, 858 KB

english, 2000

50

4,5-Dianilinophthalimide: a protein-tyrosine kinase inhibitor with selectivity for the epidermal growth factor receptor signal transduction pathway and potent in vivo antitumor activity.

Buchdunger, E, Trinks, U, Mett, H, Regenass, U, Müller, M, Meyer, T, McGlynn, E, Pinna, L a, Traxler, P, Lydon, N B

Journal:

Proceedings of the National Academy of Sciences of the United States of America

Year:

1994

Language:

english

File:

PDF, 1.33 MB

english, 1994

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